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Christina Applegate says she is still ‘your warrior’ after MS misdiagnosis

The actor told listeners of her MeSsY podcast that she will keep speaking up for people with MS while doctors investigate symptoms she says have continued and worsened.

Christina Applegate at a Paley Center event in 2012.
File photograph of Christina Applegate at the Up All Night cast event at the Paley Center in 2012. Christina Applegate 2012 — MingleMediaTVNetwork (resized and converted to WebP). CC BY-SA 2.0.Image sourceImage licence: CC BY-SA 2.0
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Christina Applegate said on the October 27 episode of her MeSsY podcast that she will keep advocating for people with multiple sclerosis after learning she had been misdiagnosed. The actor also described symptoms she says are getting worse, with their cause still unknown.

“I’m still your warrior, and I’m still going to speak out on your behalf forever and ever,” Applegate told listeners. She said she had grown close to the people with MS she has met through the podcast and still feels part of their community, even though she says she does not have the disease.

What Applegate said about her health

Applegate revealed the misdiagnosis on MeSsY the previous week, according to Rolling Stone, which reported that she had learned about it earlier in 2026. She told co-host Jamie-Lynn Sigler that the news had not brought an improvement in her health: “I haven’t gotten better, Jamie. If anything, I’ve gotten worse in some ways.” She said she was back at square one while her doctors investigate what has been happening since 2021.

On the new episode, Applegate described taking about 10 minutes to get off her pillow, out of bed and onto her feet. She said she then almost could not walk to the bathroom and now keeps a walker beside her bed. She also said she had recently lost what she considered too much weight. These are Applegate’s accounts of her symptoms; she said she did not know what was causing them.

Why the MS community matters to Applegate

Applegate disclosed an MS diagnosis in 2021 and later became a public advocate for people living with the disease. She and Sigler, who has MS, host MeSsY together. Rolling Stone reported that Applegate worried the misdiagnosis meant she had let the community down after the pair became closely associated with it. Her message to listeners this week was that she intends to stay involved.

The earlier podcast episode also featured a doctor who said MS misdiagnoses are fairly common because there is no single definitive test for the condition, Rolling Stone reported. That context does not explain Applegate’s symptoms. For now, she says her doctors are trying to find out what has been happening to her since 2021.

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