College football picks: Coaches know all too well seasons can turn against most unlikely opponents

Sometimes a team just has another team’s number until it doesn’t. That’s part of what makes college football so fun. Several matchups Saturday pit teams that had seasons ruined by an upset loss to opponents they otherwise dominated throughout history. Sometimes the loss fueled the fire for the future. Ohio State's playoff hopes died when it got blown out by Iowa in 2017. A loss to Vanderbilt launched Georgia's run to the national championship game the following year.

A loss to North Carolina in 2008 was the beginning of the end for Charlie Weis at Notre Dame.

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